Warning: pg_query(): Query failed: ERROR: missing chunk number 0 for toast value 29512337 in pg_toast_2619 in /dati/webiit-old/includes/database.pgsql.inc on line 138 Warning: ERROR: missing chunk number 0 for toast value 29512337 in pg_toast_2619 query: SELECT data, created, headers, expire, serialized FROM cache_page WHERE cid = 'https://www-old.iit.cnr.it/en/node/58363' in /dati/webiit-old/includes/database.pgsql.inc on line 159 Warning: pg_query(): Query failed: ERROR: missing chunk number 0 for toast value 29512337 in pg_toast_2619 in /dati/webiit-old/includes/database.pgsql.inc on line 138 Warning: ERROR: missing chunk number 0 for toast value 29512337 in pg_toast_2619 query: SELECT data, created, headers, expire, serialized FROM cache_page WHERE cid = 'https://www-old.iit.cnr.it/en/node/58363' in /dati/webiit-old/includes/database.pgsql.inc on line 159 Early modifications of circulating microRNAs levels in metastatic colorectal cancer patients treated with regorafenib | IIT - CNR - Istituto di Informatica e Telematica
IIT Home Page CNR Home Page

Early modifications of circulating microRNAs levels in metastatic colorectal cancer patients treated with regorafenib

Biomarkers able to improve the cost/benefit ratio are urgently needed for metastatic colorectal cancer patients that are eligible to receive regorafenib. Here, we measured plasma levels of ten circulating microRNAs (c-miRNAs) and we investigated their early changes during treatment, as well as possible correlation with clinical outcome. Ten literature-selected c-miRNAs were quantified by qRT-PCR on plasma samples collected at baseline (d1) and after 15 days of treatment (d15). C-miRNAs showing significant changes were further analyzed to establish correlations with outcome. A decision tree-based approach was employed to define a c-miRNA signature able to predict the outcome. Results achieved in an exploratory cohort were tested in a validation group. In the exploratory cohort (n = 34), the levels of c-miR-21 (p = 0.06), c-miR-141 (p = 0.04), and c-miR-601 (p = 0.01) increased at d15 compared with d1. A c-miRNA signature involving c-miR-21, c-miR-221, and c-miR-760 predicted response to treatment (p < 0.0001) and was significantly associated to PFS (HR = 10.68; 95% CI 3.2–35.65; p < 0.0001). In the validation cohort (n = 36), the increase in c-miR-21 (p = 0.02) and c-miR-601 (p = 0.02) levels at d15 was confirmed, but the associations with outcome were not. Our data indicate that early changes of c-miRNA levels might be influenced by regorafenib treatment. However, further studies are needed to establish the predictive power of such modifications.

The Pharmacogenomics Journal , 2019

IIT authors:

Type: Contributo in rivista ISI
Field of reference: Computer Science & Engineering

File: Schirripa et al. - 2019 - Early modifications of circulating microRNAs levels in metastatic colorectal cancer patients treated with rego.pdf

Activity: Biologia computazionale